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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
29.09
Human Site:
S781
Identified Species:
40
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S781
E
E
V
N
K
M
E
S
Q
L
Q
N
D
S
K
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S781
E
E
V
N
K
M
E
S
Q
L
Q
N
D
S
K
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S780
E
E
V
N
K
M
E
S
Q
L
Q
N
D
S
K
Dog
Lupus familis
XP_535848
1288
147094
S781
E
E
V
N
R
M
E
S
Q
L
Q
R
D
S
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S779
E
E
V
N
K
M
E
S
Q
L
E
R
H
S
K
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
E733
H
L
A
L
N
L
Q
E
K
S
K
L
E
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
E616
K
G
Q
V
R
E
L
E
A
N
V
L
A
A
A
Chicken
Gallus gallus
NP_989849
1274
145838
S752
E
E
V
N
R
L
E
S
E
L
Q
R
D
S
Q
Frog
Xenopus laevis
P50532
1290
146971
N775
D
Q
L
Q
K
M
E
N
K
L
K
T
D
T
T
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S780
E
Q
L
D
K
M
E
S
A
L
N
K
E
V
T
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
K776
A
E
L
D
S
M
E
K
R
L
N
E
K
V
S
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
A1094
E
R
L
E
I
T
N
A
E
L
Q
H
K
E
K
Honey Bee
Apis mellifera
XP_396862
1282
148175
S718
I
D
I
E
I
L
Q
S
N
L
N
K
T
Y
E
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
A787
Q
V
T
P
E
D
K
A
A
E
R
D
L
A
E
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
T780
Q
V
V
A
A
M
E
T
E
L
E
Q
C
R
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
A724
S
G
E
A
V
A
N
A
E
N
E
L
S
K
I
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
V851
D
D
Y
T
P
E
E
V
D
K
I
E
R
E
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
80
N.A.
80
6.6
N.A.
0
66.6
33.3
40
26.6
26.6
13.3
0
26.6
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
46.6
N.A.
20
93.3
80
66.6
46.6
53.3
46.6
53.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
6
12
6
6
0
18
18
0
0
0
6
12
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% C
% Asp:
12
12
0
12
0
6
0
0
6
0
0
6
36
0
0
% D
% Glu:
48
42
6
12
6
12
65
12
24
6
18
12
12
12
18
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
6
0
0
0
0
0
0
0
0
0
0
6
6
0
0
% H
% Ile:
6
0
6
0
12
0
0
0
0
0
6
0
0
0
6
% I
% Lys:
6
0
0
0
36
0
6
6
12
6
12
12
12
6
30
% K
% Leu:
0
6
24
6
0
18
6
0
0
71
0
18
6
0
6
% L
% Met:
0
0
0
0
0
53
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
36
6
0
12
6
6
12
18
18
0
0
0
% N
% Pro:
0
0
0
6
6
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
12
6
6
0
0
12
0
30
0
36
6
0
0
12
% Q
% Arg:
0
6
0
0
18
0
0
0
6
0
6
18
6
6
0
% R
% Ser:
6
0
0
0
6
0
0
48
0
6
0
0
6
42
6
% S
% Thr:
0
0
6
6
0
6
0
6
0
0
0
6
6
6
12
% T
% Val:
0
12
42
6
6
0
0
6
0
0
6
0
0
12
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
6
0
0
0
0
0
0
0
0
0
0
6
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _